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Description
Cullin4A-RBX1-DDB1-CRBN ProteinProduct Specification Species Human Synonyms CUL4A RBX1 DDB1 CRBN Complex Amino Acid Sequence His RBX1 (full length), HA DDB1 (full length), Cullin4A (full length), CRBN (full length) Expression System Baculovirus InsectCells Purity 90% by SDS PAGE Endotoxin <1EU g Conjugation Unconjugated Physical Appearance Liquid Storage Buffer 50 mM Tris, 200 mM NaCl, 2 mM TCEP, pH 8. 0 Stability & Storage Store at 80C. Avoid multiple freeze thaw cycles.
Product Specification
| Species | Human |
| Synonyms | CUL4A/RBX1/DDB1/CRBN Complex |
| Amino Acid Sequence |
His-RBX1 (full-length),
HA-DDB1 (full-length),
Cullin4A (full-length),
CRBN (full-length) |
| Expression System | Baculovirus-InsectCells |
| Purity | ＞90% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | 50 mM Tris, 200 mM NaCl, 2 mM TCEP, pH 8.0 |
| Stability & Storage | Store at -80ºC. Avoid multiple
freeze-thaw cycles. |
Background
Cullin-4A (CUL4A) is a core component of multiple cullin-RING type Ubiquitin ligase complexes that mediate the ubiquitination of proteins involved in cell cycle progression, DNA repair and other processes. In the DCX complex (DDB1-CUL4-X-box), CUL4A serves as a scaffold that organizes the DDB1-X-box substrate recognition subunits with the RBX1 subunit and contributes to catalysis through positioning of the substrate and an E2 ubiquitin-conjugating enzyme. In vivo, the E3 ubiquitin ligase activity of the DCX complex is dependent on neddylation of the CUL4 subunit, though neddylation may be dispensable in some in vitro reactions.
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